Platinum Nanoparticles Attenuate Aging-Like Skin Atrophy via Antioxidant Activity in Mice
Skin atrophy is a common problem associated with aging, in which skin becomes thin and fragile. In this study, we evaluated the effects of Pt nanocolloids on the restoration of skin atrophy induced by Sod1 loss in mice using both biochemical and histological approaches. After treatment with Pt colloids for 28 days, skin thickness was significantly increased compared to that in control mice. The MLSSSSR fluorescence intensity in the dermis was also increased after treatment with Pt colloids compared with that in control mice; however, this increase was not statistically significant (Figure 3B).